Sympathetic renal denervation for resistant hypertension : impact on blood pressure and on surrogate markers of target organ damage / Manuel de Sousa Almeida ; orient. Ana Aleixo... [et al.]
Main Author Almeida, Manuel de Sousa Secondary Author Aleixo, Ana Maria BrancoNeuparth, Nuno Manuel Barreiros
Gonçalves, Nuno de Araújo Language Inglês. Publication Lisboa : NOVA Medical School, 2018 Description xix, 166 p. : il. Abstract Summary Hypertension is a leading cause of death in developed countries, and although there have been large investments in drugs aiming its control, there is still a staggering contrast between its high prevalence and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases. Topical name Sympathetic Renal Denervation
Blood pressure
Surrogate markers
Academic Dissertation Index terms Tese de Doutoramento
Universidade NOVA de Lisboa
NOVA Medical School
2018 CDU 616 Online Resources Click here to access the eletronic resource http://hdl.handle.net/10362/71219 List(s) this item appears in: Teses NL
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
| Documento Eletrónico | Biblioteca NMS|FCM | ALM17 TeseD-2018 | Presencial/Restrito | 20210104NL |
Summary Hypertension is a leading cause of death in developed countries, and although there have been large investments in drugs aiming its control, there is still a staggering contrast between its high prevalence and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases.
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