Associação entre alterações da composição corporal e o perfil cardiometabólico após cirurgia metabólica e bariátrica / Mafalda Ribeiro de Sousa Lickfold ; orient. Catarina Roquette Durão
Main Author Lickfold, Mafalda Ribeiro de Sousa Secondary Author Durão, Catarina Roquette Language Português. Country Portugal. Publication Lisboa : NOVA Medical School, Universidade NOVA de Lisboa, 2022 Description 40 p. Dissertation Note or Thesis: Dissertação de MestradoNutrição Humana e Metabolismo
2022
Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Abstract Background: Some evidence suggests that different changes in body composition after Metabolic and Bariatric Surgery (MBS) may be distinctly associated with specific cardiometabolic outcomes. However, evidence is scarce and longitudinal studies describing body composition changes and their association with cardiometabolic markers are warranted. Objective: To evaluate the association of weight and body composition changes with the cardiometabolic profile, after MBS, considering a possible heterogeneity between Roux-en-Y Gastric Bypass (Bypass) and Sleeve Gastrectomy (Sleeve). Methodology: Longitudinal retrospective study in patients undergoing MBS at CUF Tejo Hospital, between September 2018 and March 2021.Anthropometric and body composition assessment data [weight, BMI, Fat Mass (FM) and Skeletal Muscle Mass (SMM)],as well as cardiometabolic markers [Total Cholesterol (TC), LDL, HDL and VLDL, Triacylglycerols, Fasting Glucose (FG) and Glycated Haemoglobin A1c], were collected in the electronic medical record from the preoperative evaluation until the follow-up of 6 months post-surgery, at four time points (pre surgery, 1, 3, and 6 months after surgery). Associations of anthropometric and body composition changes with cardiometabolic outcomes were estimated by regression coefficients (ẞ) and respective 95% confidence intervals (95%CI) by separate linear regression models for each marker. Results: No significant heterogeneity was observed between Bypass and Sleeve on the association with cardiometabolic markers. One month after surgery, we observed that decreased weight and BMI were significantly associated with lower HDL cholesterol levels at 3 months (ß=- 2,118 mg/dL; 95%CI: -2,970; -1,267; ß=-7,192 mg/dL; 95%CI: -9,485 ; -4,900, respectively).A decreased in SMM at 3 months after MBS, was associated with lower HDL cholesterol and TC at 6 months (ß=-9,612 mg/dL; 95%CI: -13,583; -5,640; ß=-16;296 mg/dL; 95%CI: -29,243; -3,349, respectively). After adjustment for sociodemographic characteristics, no significant associations were observed with the remaining cardiometabolic markers. Conclusion: Weight loss and the corresponding decrease in BMI are associated with a decrease in HDL cholesterol at 3 and 6 months of follow-up, with loss of SMM being the factor most strongly associated with this decrease. Topical name Metabolic and Bariatric Surgery
Sleeve Gastrectomy
Roux-en-Y Bypass
Cardiometabolic Markers
Body Composition
Academic Dissertation
Portugal Online Resources Click here to access the eletronic resource http://hdl.handle.net/10362/148132
| Item type | Current location | Call number | url | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Documento Eletrónico | Biblioteca NMS|FCM online | RUN | http://hdl.handle.net/10362/148132 | Available | 20230021 |
Dissertação de Mestrado Nutrição Humana e Metabolismo 2022 Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Background: Some evidence suggests that different changes in body composition after Metabolic and Bariatric Surgery (MBS) may be distinctly associated with specific cardiometabolic outcomes. However, evidence is scarce and longitudinal studies describing body composition changes and their association with cardiometabolic markers are warranted. Objective: To evaluate the association of weight and body composition changes with the cardiometabolic profile, after MBS, considering a possible heterogeneity between Roux-en-Y Gastric Bypass (Bypass) and Sleeve Gastrectomy (Sleeve). Methodology: Longitudinal retrospective study in patients undergoing MBS at CUF Tejo Hospital, between September 2018 and March 2021.Anthropometric and body composition assessment data [weight, BMI, Fat Mass (FM) and Skeletal Muscle Mass (SMM)],as well as cardiometabolic markers [Total Cholesterol (TC), LDL, HDL and VLDL, Triacylglycerols, Fasting Glucose (FG) and Glycated Haemoglobin A1c], were collected in the electronic medical record from the preoperative evaluation until the follow-up of 6 months post-surgery, at four time points (pre surgery, 1, 3, and 6 months after surgery). Associations of anthropometric and body composition changes with cardiometabolic outcomes were estimated by regression coefficients (ẞ) and respective 95% confidence intervals (95%CI) by separate linear regression models for each marker. Results: No significant heterogeneity was observed between Bypass and Sleeve on the association with cardiometabolic markers. One month after surgery, we observed that decreased weight and BMI were significantly associated with lower HDL cholesterol levels at 3 months (ß=- 2,118 mg/dL; 95%CI: -2,970; -1,267; ß=-7,192 mg/dL; 95%CI: -9,485 ; -4,900, respectively).A decreased in SMM at 3 months after MBS, was associated with lower HDL cholesterol and TC at 6 months (ß=-9,612 mg/dL; 95%CI: -13,583; -5,640; ß=-16;296 mg/dL; 95%CI: -29,243; -3,349, respectively). After adjustment for sociodemographic characteristics, no significant associations were observed with the remaining cardiometabolic markers. Conclusion: Weight loss and the corresponding decrease in BMI are associated with a decrease in HDL cholesterol at 3 and 6 months of follow-up, with loss of SMM being the factor most strongly associated with this decrease.
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