Cervical squamous cell carcinoma (SCC) and cervical intraepithelial lesions (SILS) in hiv women : contribution of the local immune response / Maria José Brito ; orient. Ana Félix, Catarina Martins
Main Author Brito, Maria José Santos Rosa Carneiro de Language Inglês. Country Portugal. Publication Lisboa : NOVA Medical School, Universidade NOVA de Lisboa, 2023 Description 154 p. Dissertation Note or Thesis: Tese de DoutoramentoMedicina
2023
Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Abstract Introduction Cervical cancer is the 4th most common type of cancer worldwide in the female population and has an increased prevalence in HIV infected women. A brief review of the mechanisms of action of HIV and HPV and of the current knowledge on the development of cervical cancer and their interactions with the cervical immunity was done. Additionally, we presented a systematic literature review of HIV infection and cervical intra-epithelial lesions and cancer, focused on the epidemiology and association with HPV (Human Papilloma Virus) infection and combined anti-retroviral therapy (cART) that illustrates the importance of the morphological studies’ contribution to this topic. Objectives Our main objective was to investigate, in HIV infected women, the local cervical immune response to HPV infection, the prevalence of different types of HPV and the expression of the programmed death ligand 1 (PD-L1), specifically in cervical intra-epithelial lesions and squamous cell carcinoma, in comparison with HIV non-nfected women. The specific objectives aimed to: Perform a systematic review of the incidence of lesions and cervical carcinoma in HIV+ population; investigate the ability to detect HIV mRNA in routine screening cervical liquid- based cytology (LBC) samples and its correlation with HPV co-infection and cervical intraepithelial lesions; characterise cervical lymphocyte subsets in HIV+ and HIV- women in cervical lavage samples (CVL) and investigate how these relate to HPV and HPV-associated cervical lesions; analyse cervical lymphocytic populations in HIV+ and HIV- patients and correlate different cervical lesions with HIV viral load and presence of high-risk HPV types; analyse the expression of PD-L1 in SCC and SILs of HIV positive patients in comparison with HIV negative patients, evaluating if the immune expression of PD-L1 in the tissues was present or not in initial steps of carcinogenesis and if there were differences between the 2 groups of patients Topical name Squamous Cell Carcinoma of Head and Neck
Squamous Intraepithelial Lesions
HIV
Women
Immunity
Academic Dissertation Online Resources Click here to access the eletronic resource http://hdl.handle.net/10362/160546
| Item type | Current location | Call number | url | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Documento Eletrónico | Biblioteca NMS|FCM online | RUN | http://hdl.handle.net/10362/160546 | Available | 20240008 |
Tese de Doutoramento Medicina 2023 Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Introduction Cervical cancer is the 4th most common type of cancer worldwide in the female population and has an increased prevalence in HIV infected women. A brief review of the mechanisms of action of HIV and HPV and of the current knowledge on the development of cervical cancer and their interactions with the cervical immunity was done. Additionally, we presented a systematic literature review of HIV infection and cervical intra-epithelial lesions and cancer, focused on the epidemiology and association with HPV (Human Papilloma Virus) infection and combined anti-retroviral therapy (cART) that illustrates the importance of the morphological studies’ contribution to this topic. Objectives Our main objective was to investigate, in HIV infected women, the local cervical immune response to HPV infection, the prevalence of different types of HPV and the expression of the programmed death ligand 1 (PD-L1), specifically in cervical intra-epithelial lesions and squamous cell carcinoma, in comparison with HIV non-nfected women. The specific objectives aimed to: Perform a systematic review of the incidence of lesions and cervical carcinoma in HIV+ population; investigate the ability to detect HIV mRNA in routine screening cervical liquid- based cytology (LBC) samples and its correlation with HPV co-infection and cervical intraepithelial lesions; characterise cervical lymphocyte subsets in HIV+ and HIV- women in cervical lavage samples (CVL) and investigate how these relate to HPV and HPV-associated cervical lesions; analyse cervical lymphocytic populations in HIV+ and HIV- patients and correlate different cervical lesions with HIV viral load and presence of high-risk HPV types; analyse the expression of PD-L1 in SCC and SILs of HIV positive patients in comparison with HIV negative patients, evaluating if the immune expression of PD-L1 in the tissues was present or not in initial steps of carcinogenesis and if there were differences between the 2 groups of patients
Click on an image to view it in the image viewer
There are no comments for this item.