000 nam a22 4500
001 16319
090 _a16319
100 _a20240108d2023 k||y0pory50 ba
101 _aeng
102 _aPT
200 _aCervical squamous cell carcinoma (SCC) and cervical intraepithelial lesions (SILS) in hiv women
_econtribution of the local immune response
_fMaria José Brito
_gorient. Ana Félix, Catarina Martins
210 _aLisboa
_cNOVA Medical School, Universidade NOVA de Lisboa
_d2023
215 _a154 p.
328 _bTese de Doutoramento
_cMedicina
_d2023
_eFaculdade de Ciências Médicas, Universidade NOVA de Lisboa
330 _aIntroduction Cervical cancer is the 4th most common type of cancer worldwide in the female population and has an increased prevalence in HIV infected women. A brief review of the mechanisms of action of HIV and HPV and of the current knowledge on the development of cervical cancer and their interactions with the cervical immunity was done. Additionally, we presented a systematic literature review of HIV infection and cervical intra-epithelial lesions and cancer, focused on the epidemiology and association with HPV (Human Papilloma Virus) infection and combined anti-retroviral therapy (cART) that illustrates the importance of the morphological studies’ contribution to this topic. Objectives Our main objective was to investigate, in HIV infected women, the local cervical immune response to HPV infection, the prevalence of different types of HPV and the expression of the programmed death ligand 1 (PD-L1), specifically in cervical intra-epithelial lesions and squamous cell carcinoma, in comparison with HIV non-nfected women. The specific objectives aimed to: Perform a systematic review of the incidence of lesions and cervical carcinoma in HIV+ population; investigate the ability to detect HIV mRNA in routine screening cervical liquid- based cytology (LBC) samples and its correlation with HPV co-infection and cervical intraepithelial lesions; characterise cervical lymphocyte subsets in HIV+ and HIV- women in cervical lavage samples (CVL) and investigate how these relate to HPV and HPV-associated cervical lesions; analyse cervical lymphocytic populations in HIV+ and HIV- patients and correlate different cervical lesions with HIV viral load and presence of high-risk HPV types; analyse the expression of PD-L1 in SCC and SILs of HIV positive patients in comparison with HIV negative patients, evaluating if the immune expression of PD-L1 in the tissues was present or not in initial steps of carcinogenesis and if there were differences between the 2 groups of patients
606 _aSquamous Cell Carcinoma of Head and Neck
606 _aSquamous Intraepithelial Lesions
606 _aHIV
606 _aWomen
606 _aImmunity
606 _aAcademic Dissertation
700 _aBrito
_bMaria José Santos Rosa Carneiro de
801 _aPT
_bNMS
_gRPC
856 _uhttp://hdl.handle.net/10362/160546
942 _cDLEC
_n0