Hipólito, Ana Rita Crispim
Cysteine metabolic remodeilng [Tese de Doutoramento] : a metabolic marker for cancer aggressiveness and a noval putative target in oncological management / Ana Hipólito ; orient. Jacinta Serpa... [et al.]
Cysteine metabolic remodeilng [Tese de Doutoramento] : a metabolic marker for cancer aggressiveness and a noval putative target in oncological management / Ana Hipólito ; orient. Jacinta Serpa... [et al.] . - Lisboa : NOVA Medical School, Universidade NOVA de Lisboa, 2024 . - 189 p. . -
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Cancer remains a major health issue and one of the most frequent causes of death. The present work explores the central role of cysteine metabolic remodeling, an often overlooked yet pivotal phenomenon with substantial implications, in the field of carcinogenesis and cancer response. The central objective of this thesis was to clarify the intricate role of cysteine metabolic remodeling in highly prevalent and lethal forms of cancer that lack effective therapeutic solutions against resistance and advanced disease. Results indicate the significance of cysteine metabolic rewiring, under the regulatory influence of BRD9 status, in shaping the aggressiveness of cutaneous melanoma (CM) through MST modulation. Furthermore, this thesis underscores the value of metabolic profiling, specifically focused on cysteine metabolism, in stratifying patients for tailored therapy in non-small cell lung cancer (NSCLC) and demonstrates the feasibility of inhibiting cysteine metabolism as a novel therapeutic avenue for NSCLC, colorectal cancer (CRC), and breast cancer (BC). Overall, this work offers prospects for identifying cysteine metabolism as a new and complex therapeutic target and reveals the hidden potential of cysteine metabolic remodeling in the intricate landscape of cancer biology Cysteine
Melanoma, Cutaneous Malignant
Carcinoma, Non-Small-Cell Lung
Breast Neoplasms
Academic Dissertation
Cysteine metabolic remodeilng [Tese de Doutoramento] : a metabolic marker for cancer aggressiveness and a noval putative target in oncological management / Ana Hipólito ; orient. Jacinta Serpa... [et al.] . - Lisboa : NOVA Medical School, Universidade NOVA de Lisboa, 2024 . - 189 p. . -
. -
Cancer remains a major health issue and one of the most frequent causes of death. The present work explores the central role of cysteine metabolic remodeling, an often overlooked yet pivotal phenomenon with substantial implications, in the field of carcinogenesis and cancer response. The central objective of this thesis was to clarify the intricate role of cysteine metabolic remodeling in highly prevalent and lethal forms of cancer that lack effective therapeutic solutions against resistance and advanced disease. Results indicate the significance of cysteine metabolic rewiring, under the regulatory influence of BRD9 status, in shaping the aggressiveness of cutaneous melanoma (CM) through MST modulation. Furthermore, this thesis underscores the value of metabolic profiling, specifically focused on cysteine metabolism, in stratifying patients for tailored therapy in non-small cell lung cancer (NSCLC) and demonstrates the feasibility of inhibiting cysteine metabolism as a novel therapeutic avenue for NSCLC, colorectal cancer (CRC), and breast cancer (BC). Overall, this work offers prospects for identifying cysteine metabolism as a new and complex therapeutic target and reveals the hidden potential of cysteine metabolic remodeling in the intricate landscape of cancer biology Cysteine
Melanoma, Cutaneous Malignant
Carcinoma, Non-Small-Cell Lung
Breast Neoplasms
Academic Dissertation
