Cysteine metabolic remodeilng : a metabolic marker for cancer aggressiveness and a noval putative target in oncological management [Tese de Doutoramento] / Ana Hipólito ; orient. Jacinta Serpa... [et al.]
Main Author Hipólito, Ana Rita Crispim Secondary Author Serpa, JacintaVicente, João B.
Bonifácio, João B. Language Inglês. Country Portugal. Publication Lisboa : NOVA Medical School, Universidade NOVA de Lisboa, 2024 Description 189 p. Dissertation Note or Thesis: Tese de Doutoramento
Ciências da Saúde
2024
Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Abstract Cancer remains a major health issue and one of the most frequent causes of death. The present work explores the central role of cysteine metabolic remodeling, an often overlooked yet pivotal phenomenon with substantial implications, in the field of carcinogenesis and cancer response. The central objective of this thesis was to clarify the intricate role of cysteine metabolic remodeling in highly prevalent and lethal forms of cancer that lack effective therapeutic solutions against resistance and advanced disease. Results indicate the significance of cysteine metabolic rewiring, under the regulatory influence of BRD9 status, in shaping the aggressiveness of cutaneous melanoma (CM) through MST modulation. Furthermore, this thesis underscores the value of metabolic profiling, specifically focused on cysteine metabolism, in stratifying patients for tailored therapy in non-small cell lung cancer (NSCLC) and demonstrates the feasibility of inhibiting cysteine metabolism as a novel therapeutic avenue for NSCLC, colorectal cancer (CRC), and breast cancer (BC). Overall, this work offers prospects for identifying cysteine metabolism as a new and complex therapeutic target and reveals the hidden potential of cysteine metabolic remodeling in the intricate landscape of cancer biology Topical name Cysteine
Melanoma, Cutaneous Malignant
Carcinoma, Non-Small-Cell Lung
Breast Neoplasms
Academic Dissertation Online Resources Click here to access the eletronic resource http://hdl.handle.net/10362/164403
| Item type | Current location | Call number | url | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Documento Eletrónico | Biblioteca NMS|FCM online | RUN | http://hdl.handle.net/10362/164403 | Available | 20240054 |
Tese de Doutoramento Ciências da Saúde 2024 Faculdade de Ciências Médicas, Universidade NOVA de Lisboa
Cancer remains a major health issue and one of the most frequent causes of death. The present work explores the central role of cysteine metabolic remodeling, an often overlooked yet pivotal phenomenon with substantial implications, in the field of carcinogenesis and cancer response. The central objective of this thesis was to clarify the intricate role of cysteine metabolic remodeling in highly prevalent and lethal forms of cancer that lack effective therapeutic solutions against resistance and advanced disease. Results indicate the significance of cysteine metabolic rewiring, under the regulatory influence of BRD9 status, in shaping the aggressiveness of cutaneous melanoma (CM) through MST modulation. Furthermore, this thesis underscores the value of metabolic profiling, specifically focused on cysteine metabolism, in stratifying patients for tailored therapy in non-small cell lung cancer (NSCLC) and demonstrates the feasibility of inhibiting cysteine metabolism as a novel therapeutic avenue for NSCLC, colorectal cancer (CRC), and breast cancer (BC). Overall, this work offers prospects for identifying cysteine metabolism as a new and complex therapeutic target and reveals the hidden potential of cysteine metabolic remodeling in the intricate landscape of cancer biology
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